Showing posts with label science. Show all posts
Showing posts with label science. Show all posts

Thursday, September 26, 2013

How big of a role does environment play in addiction?


What role does environment and distress play in addiction? Below is an interesting scientific study whose controversial findings were published in a respectable journal named Psychopharmacology back in 1978 which lead to the university terminating the project. It would be interesting to see what role stressful environments impact other forms of addiction. Also how communities could be improved to lower suffering and self destructive behavior. If scientific freedom actually existed and projects were funded for the good of humanity in lieu of profits and mechanisms of control we would all live in a much happier world. Something defiantly worth exploring.. 

medium_1F1050031-rat-park-enclosure-photograph-landscape-600px

It's not the morphine, it's the size of the cage: Rat Park experiment upturns conventional wisdom about addiction

We all learned this in DARE class. About the rats in a cage who can self-administer morphine who get addicted to the stuff, and then just hit that lever until they die. A seemingly keystone argument in the war against drugs. Professor Avram Goldstein, the creator of that study, has said: "A rat addicted to heroin is not rebelling against society, is not a victim of socioeconomic circumstances, is not a product of a dysfunctional family, and is not a criminal. The rat's behavior is simply controlled by the action of heroin (actually morphine, to which heroin is converted in the body) on its brain." So, it's the drug, and its addictive control. Surely we must eradicate drugs as a result! 

But there's another model out there by researcher Bruce Alexander of Simon Fraser University called Rat Park. From that wikipedia page: 

Alexander's hypothesis was that drugs do not cause addiction, and that the apparent addiction to opiate drugs commonly observed in laboratory rats exposed to it is attributable to their living conditions, and not to any addictive property of the drug itself. He told the Canadian Senate in 2001 that prior experiments in which laboratory rats were kept isolated in cramped metal cages, tethered to a self-injection apparatus, show only that "severely distressed animals, like severely distressed people, will relieve their distress pharmacologically if they can."

To test his hypothesis, Alexander built Rat Park, an 8.8 m2 (95 sq ft) housing colony, 200 times the square footage of a standard laboratory cage. There were 16–20 rats of both sexes in residence, an abundance of food, balls and wheels for play, and enough space for mating and raising litters. The results of the experiment appeared to support his hypothesis. Rats who had been forced to consume morphine hydrochloride for 57 consecutive days were brought to Rat Park and given a choice between plain tap water and water laced with morphine. For the most part, they chose the plain water. "Nothing that we tried," Alexander wrote, "... produced anything that looked like addiction in rats that were housed in a reasonably normal environment." Control groups of rats isolated in small cages consumed much more morphine in this and several subsequent experiments.

And so rats that are born into extreme conditions in small cages are clearly more likely to self-medicate. Tom Stafford of the BBC writes: 

The results are catastrophic for the simplistic idea that one use of a drug inevitably hooks the user by rewiring their brain. When Alexander's rats were given something better to do than sit in a bare cage they turned their noses up at morphine because they preferred playing with their friends and exploring their surroundings to getting high.

Further support for his emphasis on living conditions came from another set of tests his team carried out in which rats brought up in ordinary cages were forced to consume morphine for 57 days in a row. If anything should create the conditions for chemical rewiring of their brains, this should be it. But once these rats were moved to Rat Park they chose water over morphine when given the choice, although they did exhibit some minor withdrawal symptoms.

You can read more about Rat Park in the original scientific report. A good summary is in this comic by Stuart McMillen.

So, if Rat Park is to be believed, drug addiction is a situation that arises from poor socioeconomic conditions. From literally being a rat in a cage. If you're a rat in a park, you'd rather hang out with your friends and explore the world around you. 

Perhaps it's time the war on drugs becomes a war on the existence of poverty? (edit: Poverty of our relationships to family, community, and nation too, not merely monetary. As commenters have pointed out, there are plenty of people who have plenty of money who may well be the most poverty-ridden in other respects.)

It's not about the drugs. It's about the social environment in which we live.

Source: Garry Tan

Sunday, February 24, 2013

TEDxWhitechapel Talks

The Science Delusion: Rupert Sheldrake at

The science delusion is the belief that science already understands the nature of reality, in principle. The fundamental questions are answered, leaving only the details to be filled in. The impressive achievements of science seemed to support this confident attitude. But recent research has revealed unexpected problems at the heart of physics, cosmology, biology, medicine and psychology. Dr Rupert Sheldrake shows how the sciences are being constricted by assumptions that have hardened into dogmas. Should science be a belief-system, or a realm of enquiry? Sheldrake argues that science would be better off without its dogmas: freer, more interesting and more fun.

Rupert Sheldrake, Ph.D. is a biologist and author of more than 80 scientific papers and 10 books, including The Science Delusion. He was a Fellow of Clare College, Cambridge University, a Research Fellow of the Royal Society, Principal Plant Physiologist at ICRISAT (the International Crops Research Institute for the Semi-Arid Tropics) in Hyderabad, India, and from 2005-2010 the Director of the Perrott-Warrick Project, funded from Trinity College, Cambridge. He is a Fellow of the Institute of Noetic Sciences, Petaluma, California, and a visiting professor at the Graduate Institute in Connecticut. His website is www.sheldrake.org.

The War on Consciousness: Graham Hancock

Graham Hancock tells the story of his 24-year relationship with cannabis brought to an abrupt halt in 2011 after an encounter with Ayahuasca, the sacred visionary brew of the Amazon. Along the way he explores the mystery of death, the problem of consciousness, and the implications for the human future of a society that wages total war on true cognitive liberty.
Graham Hancock is the author of The Sign and the Seal, Fingerprints of the Gods, Keeper of Genesis, Heaven's Mirror, Supernatural and other bestselling investigations of historical mysteries.

His books have been translated into twenty-seven languages and have sold over five million copies worldwide. His public lectures and broadcasts, including two major TV series, Quest for the Lost Civilization, and Flooded Kingdoms of the Ice Age, have further established his reputation as an unconventional thinker who raises controversial questions about humanity's past. Hancock's first venture into fiction, Entangled, was published in 2010 and his second novel, War God, on the Spanish Conquest of Mexico, will be published on 30 May 2013. Hancock maintains an active Facebook presence:
http://www.facebook.com/Author.Graham.... His website is: http://www.grahamhancock.com.

Wednesday, October 10, 2012

GMO Food Dangers

Are Genetically Engineered Foods and Crops Akin to Weapons of Mass Destruction?

Jeffrey M. Smith is the author of the world's bestselling book on the health dangers of genetically modified organisms (GMOs),

Seeds of Deception: Exposing Industry and Government Lies about the Safety of the Genetically Engineered Foods You're Eating.
His second book, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods,

is the authoritative work on GMO health dangers. It includes 65 health dangers, linking GMOs in our food to toxic and allergic reactions,
infertility, and damage to virtually every internal organ studied in lab animals.
The book summarizes why ending GM foods must urgently become our world's top food safety priority.

More Information about Jeffrey M. Smith

Download the Non-GMO Shopping Guide Brochure

What should every person know about the food they ingest. The documentary "The Future of Food" changed the way we think about food(and continues to do so) by answering this very question.

But, just how has food actually changed? Do we need to worry about genetically modified foods? What about artificial foods? Learn all this more as Kurt Olson, host of the Educational Forum, sits down with Deborah Garcia the award winning creator of "The Future of Food."
The Massachusetts School of Law at Andover

FROM THE PEACE REVOLUTION PODCAST

Tuesday, September 4, 2012

Graham Hancock: Ancient Mysteries

Graham Hancock discusses his views on the following topics:

1 - Precession of the equinoxes
2 - Bringers of wisdom from the Heavens
3 - Monuments aligning to 10,500BC
4 - What happened in 10,500BC?
5 - The Mystery of the Pyramids
6 - The Sarcophagus
7 - Dating Giza
8 - Hidden Halls of Records
9 - Structures on Mars
10 - Cataclysm of Mars
11 - A species with amnesia
12 - Where is the Lost Civilization?

www.grahamhancock.com

Thursday, February 9, 2012

Trialogues: McKenna, Sheldrake, Abraham

Trialogues are from a series of lively, far-reaching discussions between Rupert Sheldrake, Ralph Abraham and Terence McKenna, that took place between 1989 and 1998, in America and England. These Mp3’s are generously hosted by Rupert on Sheldrake.org

Trialogue Sheldrake-McKenna-AbrahamThese three-way conversations began in private after their first meeting in 1982. Encouraged by their similar fascinations and complimentary views, and inspired by the synergy of their ideas and styles and the input of differing areas of expertise, the three friends continued to meet and explore new areas of thought. Throughout their public trialogues, which began in 1989, they maintained the spontaneous, playful and intrepid spirit of their private talks, and were thrilled that these explorations inspired further discussions amongst their audiences. Their trialogues and friendship have been a source of great inspiration and stimulation for their own lives and work.

In their first set of public trialogues, held as a workshop at Esalen in 1989, they explored aspects of the world soul from the perspectives of chaos, creativity and imagination, and discussed many topics including: light and vision; the psilocybin mushroom; the unconscious; entities; the resacralization of the world; the reform of the educational system and the Apocalypse.

Their second series of trialogues examined evolution in all its forms, through new topics that included: grassroots science; psychedelics, computers and mathematics; psychic animals; the World Wide Web; celestial intelligences; the nature of time and the evolving mind.

Edited transcripts of many of their first series of trialogues are published in the book Trialogues at the Edge of the West (later published as Chaos, Creativity, and Cosmic Consciousness), and many of those from their second series can be found in The Evolutionary Mind.

Terence McKenna was an ethnopharmacologist, shamanologist, and author, known for his theories on plant hallucinogens and the novelty wave, and the bardic skill with which he conveyed his ideas. Sadly Terence died aged 53 on April 3, 2000.

Ralph Abraham, PhD, is a Professor of Mathematics, author, and pioneer in the fields of Chaos theory, computer graphics, visual mathematics and dynamical systems.

Rupert Sheldrake, PhD, one of the world’s most innovative biologists and writers, is best known for his theory of morphic fields and morphic resonance.


1.
Cast of Characters
An introduction to the first series of public trialogues held at Esalen, California in 1989.

2.
The Evolutionary Mind
What could have been the cause for the breakthrough in the evolution of human consciousness around 50,000 years ago?

3..
Consciousness and Machines
A discussion on the evolution of consciousness as it relates to machines. Symbolic logic, nanotechnology and the possibility of a synthetic super-intelligence.

4.
History, Fractals and Change
The fractal idea of history, and millenia as the plateaus of history. These bifurcation periods as opportunities to influence the creation of the future.

5.
Creativity and the Imagination
The crisis in science: collision between the permanent and evolutionary views of the nature of reality. A wide-ranging discussion in two parts.

6.
Creativity and Chaos
The chaos revolution, chaotic attractors and indeterminism in nature. A comprehensive discussion in two parts.

7.
Chaos and the Imagination
How can chaos theory and full access to the imagination aid us in our understanding of the world and in the creation of our future? A discussion in 2 parts.

8
Light and Vision
How is our own vision related to light, and how is the perception of the world soul related to light? A discussion in 2 parts.

9
Entities
Are disincarnate and non-human entities mental projections or non-physical, autonomous entities? How do they relate to the world soul and how can we interpret their messages? A discussion in 2 parts.

10
The Unconscious
What is the nature of the unconscious, and how can we access its restorative powers? A discussion in 2 parts.

11
The Resacrilisation of the World
In what ways can we bring the sacred back into the world? A discussion in 2 parts.

12
Education in the New World Order
How could the educational system be reformed and resacralized? A discussion in 2 parts

13
The Apocalypse
This investigation into apocalyptic messages starts with the question of whether they are self-fulfilling prophecies or intuitions of instability.
A discussion in 2 parts.

14
Grass Roots Science
The trialoguers discuss the need for a new grassroots model of science.
A discussion in 2 parts.

15
Saving the World
The trialoguers address the problem of over-population and resource depletion.
A discussion in 2 parts.

16.
Gender Issues
Exploring gender issues and ways to heal society.
A discussion in 2 parts.

17.
Cannabis
The trialoguers discuss cannabis and its potential as a tool for cultural evolution.
A discussion in 2 parts.

18.
Crop Circles
An in-depth investigation into the mystery of crop circles.
A discussion in 2 parts.

19.
Psychedelics and the Computer Revolution
The cultural impact of psychedelics and the computer revolution.
A discussion in 2 parts

20
Fields, Brains and Chaos
Rupert and Ralph explore fields and the memory process
A discussion in 2 parts

21
A Report on Crop Circles
Further explorations into the crop circle mystery.

22.
Psychedelics and Mathematical Vision
Exploring the connection between mathematical vision and the psychedelic experience. (2 parts).

23.
The Immediate Future and the Millennium
How can society be reconstructed and improved? (2 parts).

24.
The Heavens
Rediscovering a sense of the life of nature and of the heavens. (2 parts).

25
Utopianism and Millenarianism
The ongoing cultural impact of utopianism and millenarianism. (2 parts).

26
Hazelwood Introductions
The three friends describe each others’ lives and work.

27
Homing Pigeons
Homing pigeons and the extraordinary implications of unexplained biological mysteries. (2 parts).

28
Time
New ways of understanding the nature of time. (2 parts).

29
Fractals
How fractal models can enhance our understanding of the world. (2 parts).

30
Angels, Entities and the Heavens
Recovering the links between heavenly states and the physical heavens.

31
Hawaii
In Hawaii, the trialoguers explore what Hawaii can teach us about evolution. (2 parts).

32
The World Wide Web
A trialogue from 1994 on the transformative potential of the World Wide Web (2 parts).

33
Scepticism and the Balkanization of Epistemology
A trialogue on finding the middle ground between unanchored speculation and dogmatic skepticism (2 parts).

34
Morphogenetic Family Fields
An investigation into telepathic bonds within social groups and the nature of the fields that may underlie these connections (2 parts).

McKennaAbrahamSheldrake

www.EROCx1.com

Thursday, January 26, 2012

Hallucinogen actions on human brain revealed

79413680-Neural-Correlates-of-the-Psychedelic-State-as-Determined-by-fMRI-Studies-With-PsilocybinMushrooms' magic? Tuning out is key to turning on
By: Melissa Healy
From: Los Angeles Times
Date: January 23, 2012

Psilocybin mushrooms' power to throw open the doors of perception is well documented in ancient legend and modern song. But not until now have high-tech brain-scanners captured the process by which psilocybin causes a sudden shift in human cognition. The secret to its mental magic? It appears to power down the brain's seat of reason and disconnect it from regions that process the way we see, hear and experience the world.

Those findings, gleaned by a group of British neuroscientists, were published Monday in the Proceedings of the National Academy of Sciences.

Within a minute after subjects got an infusion of psilocybin, researchers said, scanners that plot blood flow within the brain detected a sudden drop in activity in the medial prefrontal cortex and the posterior cingulate cortex, two areas of the brain that appear to be key in "grounding" us in reality. These areas also are key nodes of the brain's newly identified Default Mode Network, which springs to life when our minds wander.

Thus untethered, the brain's sensory regions are free to soar. Subjects reported unusual changes in their visual experiences, including geometric patterns, distortions of space and size, and dreamlike perceptions. They reported that their thoughts and imaginations wandered, their perceptions of time were changed, and sounds they heard brought on vivid images -- a mingling of sights, sounds and thoughts such as those experienced by people with the brain regions that showed the most consistent decline in activity under psilocybin's influence were the same brain regions that are most active in everyday cognition, said the study's authors, who come from a consortium of British universities and the University of Copenhagen in Denmark. Those regions function not only as "connective hubs" among brain regions with different functions; they are key in the kind of idle thinking in which we place ourselves at the center of our surroundings and experience.

The study's authors suggest that psilocybin's outsized effect on the brain's Default Mode Network may reveal a key function of the system. The findings suggest that a working Default Mode Network "is crucial for the maintenance of cognitive integration and constraint under normal conditions."

The study also may help suggest why psilocybin is increasingly seen as a promising treatment for a number of psychiatric conditions, including depression, addiction and post-traumatic stress disorder. By suppressing the intrusive and self-centered ruminations that are hallmarks of depression and allowing individuals to transcend themselves, drugs like psilocybin may be key to shifting perspectives and priorities, the authors wrote.

Complete Article: Neural Correlates of the Psychedelic State as Determined by fMRI Studies With Psilocybin


This article contains supporting information online at: www.pnas.org

By: Robin L. Carhart-Harrisa, David Erritzoea,Tim Williams, James M. Stone, Laurence J. Reed,  Alessandro Colasanti, Robin J. Tyacke, Robert Leech, Andrea L. Malizia, Kevin Murphy, Peter Hobden, John Evans, Amanda Feilding, Richard G. Wise, & David J. Nutt

www.GaianBotanicals.com

Saturday, August 27, 2011

Hurricane Irene Could Sprout Magic Mushrooms

Hurricane Irene Could Sprout Bumper Crop Of Magic Mushrooms
From:
www.huffingtonpost.com
By: David Moye

Psilocybe-semilanceata

Everyone knows the potential destructive power of hurricanes, but few people are aware that storms like Hurricane Irene encourage growth of psychedelic mushrooms.

Yes, it sounds trippy, but one of the strange aftermaths of a hurricane is an increased amount of mushrooms popping up -- especially the psilocybin -- or "magic" kind -- the ones that cause hallucinations.

According to Dr. Casey Simon, an addiction expert based in Orange County, Calif., hurricanes create the perfect climactic conditions for the mushrooms to grow.

"Mushrooms are spores and they multiply in moisture and are spread by wind," he told HuffPost Weird News.

Dr. Suneil Jain, a naturopathic physician in Scottsdale, Ariz., goes even further.

"The moisture, humidity, the wind and the temperature during hurricanes is the perfect climate for mushrooms," he told HuffPost Weird News. "Also, both hurricanes and mushroom growth are associated with new or full moons, so there may be a lunar element as well."

Jain says, generally, psychedelic mushrooms are noted by their bluish-gray stems, but stresses that many mushrooms can be toxic and ones picked in the wild should not be consumed unless they've been examined by an expert.

However, despite the hallucinogenic effects, he says that magic mushrooms are relatively safe.

"These substances have been used for centuries, with just a handful of cases of addiction, or long-term problems," he said. "Generally, they are fairly benign."

Recent studies by Johns Hopkins University suggest psilocybin mushrooms may have medical benefits, and Jain is one of those who believes the findings could have a positive impact on humanity.

"There is evidence that it can help in treating OCD, body dismorphia issues and even marital problems," he said.

Simon says the real danger of the mushrooms isn't the psilocybin.

"Some mushrooms can attract a fungus that makes them more toxic," he said. "It looks like a gray mold on the under side. Just a few differences in temperature can make a difference."

Jain says that's why experienced mushroom experts pick mushrooms when they are as fresh as possible.

"The optimal time to pick is right after the storm before the other elements can affect them," he said.

Still, the news that the whole East Coast of the U.S. could soon be awash in 'shrooms is bound to get every hippie worth his hemp sandals and hacky sack on the hunt for a new high.

Mushrooms are likely to pop up in locations where bark is used for decorative landscaping, like industrial parks and government offices, according to ethnobotanist Clark Heinrich

It's important to emphasize that wild mushrooms -- both mind-altering or not -- should not be consumed willy nilly, but Jain hopes to use the fact that so many potentially medicinal mushrooms will soon be popping up all over the East Coast as a way to raise a discussion about an aspect of the medical-pharmaceutical industry he doesn't like.

"There are a lot of medicinal plants that [have health benefits]," he said. "For instance, the main ingredient in statin drugs comes from red yeast rice. But instead of focusing on the plants that can heal, medical science tries to find the active ingredient, change it slightly and then market that so they can charge a lot."

"Besides that, singling out one ingredient in the plant, like psilocybin, doesn't take into account that everything in the plant, and that they all work together."

Friday, August 26, 2011

Dennis McKenna interview by Peter Gorman

Subscribe to the Psychedelic Salon Podcast

Podcast 276 – “Peter Gorman Interviews Dennis McKenna Part 1” Download Mp3
Podcast 277 – “Peter Gorman Interviews Dennis McKenna Part 2” Download Mp3
                                                               To Download, right click & save target as..

McKenna-Gorman

Guest speakers: Peter Gorman and Dennis McKenna

Recorded in 1994

[NOTE: All quotations are by Dennis McKenna.]

“The idea that you could use these to actually explore other dimensions, real worlds that were outside the cognizance of our ordinary world, is really what I think fascinated me about psychedelics.”

“More than anything else, it [DMT] seemed to be not an experience, not a drug, but a place, an actual other dimension that you were plunged into.”

“In order to understand its limitations, I almost had to become the ‘enemy’. I had to become a scientist in order to understand the limitations of science.”

“I think that Ayahuasca is actually much more controllable than mushrooms. . . . I think that it is quite an amazing tool for self-understanding and for exploration. I think that it’s good for you, actually physically and psychologically good for you.”

“It’s no different than it ever was. When the Jesuits and the missionaries came to meso-America the first things to go, the first things to be stamped out was the knowledge of the sacred plants and the practice of using the sacred plants.”

“I think that Christianity linked with Calvinism has a hard time dealing with what you might call facts of biology, which in another phrase is sex, drugs, and rock ‘n roll. In some ways, life is about sex, drugs, and rock ‘n roll. Biology is about those things.”

“All experience is a drug experience. Whether it’s mediated by our own [endogenous] drugs, or whether it’s mediated by substances that we ingest that are found in plants, cognition, consciousness, the working of the brain, it’s all a chemically mediated process. Life itself is a drug experience.”

“He [Terence McKenna] will never let a fact get in the way of making a provocative statement. He’s a good story teller, but I think it’s important to remember that they are stories, and that he often makes mistakes in his lectures.”

“In that position, a guy who can pack the houses every time, I feel has a larger responsibility to the psychedelic community to refrain from making these completely off-the-wall comments, and to actually tell it like it is, not how he imagines it to be.”

“I’m sure that Terence views it as theater. I can’t believe that he takes what he says seriously. I mean, I can tell you that he doesn’t. Much of what he says he says it because it’s going to get a rise out of somebody. He’s always been that way.”


Peter Gorman

Writer, Explorer, Naturalist

Dennis McKenna

Writer, Ethnopharmacologist, Researcher, Explorer

www.EROCx1.com • www.GaianBotanicals.com

Tuesday, May 3, 2011

UC Berkeley : Drugs and Behavior

berkeley_lg

University of California Berkeley
Psych 119 Drugs and Behavior
Instructor
David Presti, Ph.D.
Senior Lecturer of Neurobiology, his areas of expertise include the chemistry of the human nervous system, the effects of drugs on the brain and mind, and the scientific study of mind and consciousness.

Course Syllabus for 2010

ASUC Lecture Notes Online

Psych 119: Drugs and the Brain. A survey course exploring the basic principles of psychopharmacology. The major focus of the course is on the relationship between behavior and the physiological actions of drugs. Emphasis will be placed on effects of pharmacological agents on complex mental processes such as attention, motivation, learning, and memory.

Subscribe Subscribe to the Psych 119 podcast

Psych 119: Lecture 1


Psych 119: Lecture 2


Psych 119: Lecture 3


Psych 119: Lecture 4


Psych 119: Lecture 5


Psych 119: Lecture 6


Psych 119: Lecture 7


Psych 119: Lecture 8


Psych 119: Lecture 9


Psych 119 - Lecture 10


Psych 119: Lecture 11


Psych 119: Lecture 13


psych 119: Lecture 14


Psych 119: Lecture 15


Psych 119: Lecture 16


Psych 119: Lecture 17


Psych 119: Lecture 18


Psych119_Lecture 19


Psych 119: Lecture 20


Psych 119: Lecture 21


Psych 119: Lecture 22


Psych 119: Lecture 23


Psych 119: Lecture 25


Psych119: Lecture 27


Psych 119: Lecture 28


Psych 119: Lecture 29

David Presti

Quiz Answer Forms

New York City Marijuana Arrest Analysis 2008

"Letting Go: Smoking and non-smoking" by David Sedaris

Tips for Quitting Smoking

SAMHSA and NIDA Tobacco Use Data

SAMHSA Alcohol Use Data

Cannabis Prevalence Data

Some approximate caffeine contents


William James